TV Guide included her and Ellen De Generes in their Power A-List couples in 2007.In February of 2012, it was announced that ABC had ordered a pilot for a new drama series The Smart One, one of whose executive producers was listed as Ellen De Generes, and which featured de Rossi in a leading role.In April 2017, in season six, de Rossi's character, Elizabeth North, was killed off by a golf club attack.
In May of 2007, she was featured as one of 100 Most Beautiful in a People special edition.
In 2005, she explained that she had intended to reinvent herself, using the given name of Portia, a character from William Shakespeare's The Merchant of Venice, and an Italian last name.
She was educated at Melbourne Girls Grammar School and the University of Melbourne, where she studied law.
Each episode focused on one particular character, with de Rossi's Lindsay featured in Episode 3, "Indian Takers," and Episode 8, "Red Hairing," and also appearing in several other episodes of the season.
De Rossi joined Scandal in the fourth season in a recurring role, before being upped to a series regular for the fifth season.